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Cayuse Human Ethics

Cayuse HE Login Request Access to Cayuse


Beginning January 10, 2022, the Office of Research Compliance will begin to use the web-based product Cayuse Human Ethics for managing human subject research studies. Cayuse Human Ethics is an electronic protocol management platform that is cloud-based, user-friendly, and secure.

Cayuse Human Ethics enables collaboration and increases efficiency among investigators, ORC, and IRB committee members. It allows investigators to prepare, submit, and route human subjects research studies with secure electronic document technology.

Cayuse Human Ethics will be used to prepare and submit all initial human subjects research studies, as well as make modifications, request renewals, and report incidents.

Log in to Cayuse Human Ethics

Each investigator will need to have a Cayuse account before they can be added to a study submission. If you try to log in and get an error message, or if you know that you do not have a Cayuse account, fill out the Request Access to Cayuse form (link above).

All students who plan to conduct research as a Co-Investigator, Primary Contact, or as a member of the study team you may request access to Cayuse by completing the Request Access to Cayuse Office of Research staff will create your accounts and you can expect a 24-48-hour turnaround time.

For Volunteer Faculty Mentors of the TCU School of Medicine, who are not technically TCU (No TCU ID#) and will serve as Principal Investigator on behalf of a medical student, you may request guest access to Cayuse by completing the Request Access to Cayuse.

All faculty and staff accounts have already been created and you will be able to login starting on January 10th.

What about currently approved studies?

All currently approved human subject research studies deemed Exempt before January 10, 2022, will continue to submit modifications and study closures by submitting to These studies will not be migrated into Cayuse HE.

All currently active Full Board and Expedited studies (Legacy studies) will be migrated into Cayuse HE. Your legacy study shells will be created for you and your most recently approved study documents will be uploaded for you and available to download.

Help with Cayuse Human Ethics

Resource Center

Once you’ve logged in to Cayuse Human Ethics, select the orange question mark icon in the bottom right corner of the window to open the Resource Center.

  • Select Show Me How To… and choose the action you want to complete, and the system will walk you through it.
  • Select Help Center to see suggested articles, or search for a support article.